what are the neuromodulatory effect of acetylcholine, neuropeptides catecholamines, serotonin/

The neuropeptides catecholamines include dopamine, which is an inhibitory neurotransmitter found in the brain centres that control mood.Serotonin and acetylcholine which are excitatory neurotransmitters also work in the brain as well as outside[peripheral nervous system.Selective serotonin reuptake inhibitors[SSNRI] are good antidepressants,SNRI[Selective norepinephrine reuptake inhibitors] are also good antidepressants,both work at different brain centres that modulate mood.The hippocampal gyrus containing ,amygdala as well as the reticular activating system in the brain stem, that controls awakening are either inhibited to allow for sleep or excited to fight depression.acetycholine works on the mood excitation and wakefulness in the reticular activating system while the other two work at the hippocampal gyrus to alleviate depression.

Excess serotonin production can occur in argentafinoma especially when the gut is excessively stimulated by excess activity of serotonin in periphery.Also phaechromocytoma is excess actvity of acetylcholine and norepinephrine within the periphery occasioned by adrenal medullary tumor.The drugs to inhibit theirunapposed activity is the sure way to mitigate the problem.