What is the significance of the name of the town where Seq is fostered in the novel, Where the Dead Sit Talking?

The name "Little Crow" is significant, in that it is another manifestation of the novel's inclusion of birds as a symbol of Sequoyah's identity, or affinity with nature. While the city / town itself is a man-made construction, the metaphoric sense here is that the town is something of a catalyst for Sequoyah to discover important truths about himself. In other words, while actual birds represent nature, the bird-name of the town represents opportunities for Sequoyah to encounter, and become more comfortable with, his own nature.