What is the main conflict in Vineland by Thomas Pynchon?

Vineland tells the story of the people surrounding Frenesi Gates, a one-time sixties radical who turns government informer and goes into hiding, abandoning her husband and young daughter. Pynchon moves fluidly in his narrative from character to character and between the time settings of 1970 and 1984, describing a loosely-knit group of people whose lives are greatly affected as Frenesi passes through them.