The settings in The Silence of the Lambs are critical to conveying the sense of deep and abiding evil, which resides in the story's two serial killers. Hannibal Lecter's home is a cell deep within the bowels of the Baltimore State Hospital for the Criminally Insane. His cell is the very last one at the end of the hall. To reach him, one must venture through the gauntlet of madmen in the adjoining cells. In his cell, Lecter has no control over his external circumstances.