What is the theme in The Patron Saint of Liars by Ann Patchett?

Running Away is a theme in this book. Rose has never felt comfortable staying in one place. Rose's childhood is upset by the death of her father, leaving her alone with a mother who does the best she can, raising a child on her own. As Rose grows up, she sees her mother derive peace from her religion, so Rose tries to do the same. Rose thinks God will give her a sign when it is time to make choices about her future, about the life she is supposed to live. When Rose meets Thomas Clinton, she thinks he is her sign.