Tom Wolfe writes about Ken Kesey, a promising young writer, during Kesey's experimentations with LSD from about 1961 to 1964. Kesey leaves his home in Oregon to do post-graduate work on a creative writing fellowship at Stanford University. There he encounters LSD and other psychoactive drugs while volunteering as a research subject. The effects of LSD on Kesey's perceptions draw him and others into the regular use of LSD, marijuana and amphetamines. A small version of the drug culture that is to follow develops.