The use of language is an important theme in the book. From the first essay in Me Talk Pretty One Day, use of language is an evident theme. In his first essay, Sedaris discusses his clever tactic to develop his vocabulary to circumvent having his lisping "s" corrected.
In another essay he discusses his brother's colorful language, which is so laden with profanity that it is incoherent most of the time. Sedaris's brother, Paul, also speaks with a North Carolina accent, uses terms like ma'am, and other conjugates like ya'll, all of which are manners of speech that Sedaris and his other siblings made an effort to avoid. Paul's use of language implies that he is ignorant, brash, and offish, a completely the opposite of Sedaris and the characteristics that he admires.