Several settings are featured in Kiss the Girls. The primary setting is the Research Triangle area of North Carolina: Durham and Chapel Hill. These towns are home to Duke University and the University of North Carolina, respectively. The history of these towns, and the tobacco farms surrounding them, figure prominently into the plot of the novel. From the very beginning of the story, Cross is apprehensive about visiting the South. He has reason to be. He must come face to face with the history of the South and slavery that he so desperately wants to forget.