Cell biology
FROG EMBRIO
Why cleavage in frog embryo produces two different size cells?

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Why cleavage in frog embryo produces two different size cells?
Cleavage in amphibians is holoblastic, but the size of the blastomeres is very uneven. ... During cleavage, development involves only an increase of cell numbers; the shape of the embryo does not change, and chemical transformations within the embryo are restricted to those necessary for cell division.